Upstream Process Development Co-Op

At Keros, our mission is to deliver significant clinical benefit to a wide range of patients with disorders that are linked to dysfunctional signaling of the transforming growth factor-beta (TGF-ß) family of proteins. With a focus on developing differentiated product candidates that are designed to alter TGF-β signaling, we aim to target the pathways critical for the growth, repair and maintenance of blood cells and a number of tissues, including bone, skeletal muscle, adipose and heart tissue. We believe our product candidates have the potential to unlock the full therapeutic benefits of modulating the TGF-β superfamily and provide disease-modifying benefit to patients.

Job Summary

This role is responsible for media and feed preparation, execution of experiments for upstream biologics process development, routine daily maintenance of upstream equipment, and experiment data management and analysis. Organizational skills, communication skills, and recordkeeping are also critical to this role.

Primary Responsibilities

CHO mammalian cell cultures in shaker flasks, WAVE bioreactors, and benchtop bioreactors Media and feed formulation as needed for experiments Data management and analysis including metabolite, gas, cell count, and titer data Media and feed studies to support process development on early phase programs Scale-down modeling and range finding to support development and program technology transfers Depth filtration filter loading studies to develop cell culture harvest strategies Routine maintenance on upstream equipment to maintain daily functionality Core Competencies (Required Skills) Familiar with aseptic technique methods Familiar with experiment design Familiar with Microsoft Office, especially Microsoft Excel Technical and scientific writing and presentation skills Preferred Skills Mammalian cell culture Media and buffer preparation Understanding of basic engineering and biology concepts Education Requirements Currently enrolled in a chemical engine