Medicinal Chemistry Co-op (Spring 2027)

Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities including RNAi silencing and RNA editing provides us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline is focused on our obesity, alpha-1 antitrypsin deficiency and PNPLA3 I148M liver disease programs and includes clinical programs for Duchenne muscular dystrophy and Huntington’s disease, as well as several preclinical programs utilizing our versatile RNA medicines platform. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.

Description

Wave Life Sciences USA seeks a highly motivated, energetic, safety conscious and results-driven candidate to join its team of medicinal chemists in Cambridge, Massachusetts. The co-op’s role will primarily consist of laboratory work in support of the medicinal chemistry team’s efforts. The candidate will be responsible for planning, designing and executing multi-step synthesis including purification and compound characterization. The candidate will also be responsible for analysis of raw materials and final products received and maintain records. The candidate will be trained in a variety of laboratory techniques and instrumentation (including NMR, UPLC/MS, polarimeter, Isco column chromatography, benchtop rotovap, etc.), making this an excellent learning opportunity. These efforts will support the development of novel nucleic acid therapies across multiple disease areas.

Experience

• Working towards a Bachelor’s degree in chemistry or a related disciplin